已撤销的2.0更新关于已撤销的药物,包括药监数据
Kathleen Gallo1, Andrean Goede1, Oliver-Andreas Eckert1
1Charité - Universitätsmedizin Berlin, Institute of Physiology and GB IT, Science IT, Corporate Member of Freie Universität Berlin, Berlin Institute of Health, Humboldt-Universität zu Berlin, 10117 Berlin, Germany.
Nucleic acids research
|November 16, 2023
概括
这项研究增强了FDA药物监督数据和药物向预测的撤回数据库. 该资源有助于了解药物戒断和探索药物重新定位以寻找新适应症.
科学领域:
- 药监和药物开发 药物监督和药物开发
- 计算机化药物发现技术
- 药用化学 医学化学
背景情况:
- 药物开发面临的挑战是异于目标的相互作用导致副作用和戒断.
- 目标外相互作用可以为药物重新定位到新的适应症提供机会.
- 现有的关于退出药物的数据是分散在多个国家来源的.
研究的目的:
- 更新和扩展撤回数据库,以提供全面的药物监测和药物向信息.
- 促进对药物戒断和潜在的药物重新定位策略的洞察力.
- 提高已撤回的药物数据的可访问性和可用性.
主要方法:
- 美国食品和药物管理局综合不良事件报告系统 (FAERS) 药监数据.
- 增加了作用机制和人类疾病途径预测功能.
- 持续更新退出药物的清单及其相关目标.
- 实现了系统的浏览选项,如一个解剖治疗化学 (ATC) 树.
主要成果:
- 已撤回的数据库 (版本2.0) 现在包括了广泛的药监数据和预测功能.
- 通过用户友好的浏览和更新的药物清单来提高数据的可访问性.
- 更新的数据库支持对药物戒断和重新定位的研究.
结论:
- 增强的 Withdrawn 2.0 数据库为药物重新用途和安全研究提供了有价值的,公开可访问的资源.
- 改进的数据整合和可访问性简化了药物撤销和非目标效应的调查.
- 该资源支持对以前被撤销的药物识别新的治疗机会.
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