Cistrome数据浏览器:集成搜索,分析和可视化色素数据
Len Taing1, Ariaki Dandawate2, Sehi L'Yi3
1Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.
Nucleic acids research
|November 16, 2023
概括
Cistrome数据浏览器 (Cistrome DB) v3.0提供了广泛的人类和小鼠表观遗传学数据,包括ChIP-seq和ATAC-seq. 这个更新的资源增强了全基因组的调节元件分析,并改进了可视化和搜索功能.
科学领域:
- 基因组学就是基因组学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 生物信息学是一种生物信息学.
背景情况:
- "Cistrome数据浏览器"是一个精心策划的表观基因组数据资源.
- 它以前为人类和小鼠提供了访问ChIP-seq,ATAC-seq和DNase-seq数据.
- 之前的版本促进了对全基因组调节元件位置的研究.
研究的目的:
- 发布Cistrome DB版本3.0,这是一个更新和扩展的表观基因组数据分析资源.
- 改进用户界面和搜索功能,以便更有效地检索和可视化数据.
- 为预测基因调节器和理解 cis-调节元素功能提供增强的工具.
主要方法:
- 汇编和整合大约32,000个新的人类和小鼠表观基因组数据集.
- 开发一个单页应用程序用户界面,具有统一的搜索功能.
- 实现一个嵌入式基因组浏览器用于数据可视化.
- 扩大质量控制统计,添加序列标识,以及丰富元数据.
主要成果:
- Cistrome DB v3.0 包含大约 45,000 个人类和 44,000 个小鼠样本.
- 新版本提供了改进的数据搜索,包括关键字,菜单和数据驱动选项.
- 增强的可视化工具可以预测基因调节器和cis-regulatory元素的功能.
- 现在可以使用扩展质量控制,序列标志和样本元数据.
结论:
- Cistrome DB v3.0代表了Cistrome数据浏览器资源的显著扩展和改进.
- 更新后的平台有助于更有效地分析和解释全基因组表观遗传学数据.
- 该资源将帮助研究人员了解人类和小鼠的基因调节和染色质可访问性.
相关概念视频
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