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Updated: Jul 11, 2025

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
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Published on: September 1, 2019

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无序的CREB交换活化域的富含谷氨酸的区域介导动态的分子内和分子间相互作用

Maria A Martinez-Yamout1, Irem Nasir1, Sergey Shnitkind1

  • 1Department of Integrative Structural and Computational Biology and Skaggs Institute of Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037.

Proceedings of the National Academy of Sciences of the United States of America
|November 16, 2023
PubMed
概括

循环AMP反应元件 (CRE) 结合蛋白 (CREB) 交换活化域本质上是无序的,具有动态相互作用. 酸化扩大了酶诱导激活域 (KID),增强了同活性剂的结合.

关键词:
这就是NMR的NMR.五分之一 五分之一本质上是无序的蛋白质.单分子FRETET是一种单分子FRET.转录激活的转录激活

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