设计,合成,结构-活性关系和三维定量结构-活性关系的酸衍生物和类似物作为潜在的杀菌剂
Bin Bin Huang1, Ming Wei Gao1, Guo Li1
1Key Laboratory of Biopesticide and Chemical Biology (Ministry of Education), Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, People's Republic of China.
Journal of agricultural and food chemistry
|November 16, 2023
概括
酸衍生物对植物病原体如Collettotrichum higginsianum具有强大的抗真菌活性. 经过修改的丁基组的优化化合物作为新型农业杀菌剂提供了有前途的潜力.
科学领域:
- 农业科学 农业科学
- 菌类学 菌类学是指菌类学.
- 有机化学 有机化学
背景情况:
- 酸 (FA) 是Fusarium oxysporum中的天然化物,具有广泛的抗真菌特性.
- 之前的研究表明,FA对14种植物病原菌具有显著的抑制作用,特别是Colletotrichum higginsianum.
- 农用草药是开发有效农用除草剂和杀菌剂的关键前体.
研究的目的:
- 设计和合成用于农业应用的新型酸衍生物.
- 为了评估这些衍生物对关键植物病原菌的抗真菌活性.
- 识别具有高效率和进一步发展为杀菌剂的潜力的化合物.
主要方法:
- 三系列酸衍生物的合成.
- 在体外测试抗真菌活性对Collettotrichum higginsianum,Harpophora maydis和Pyricularia grisea.
- 使用处理指数对大米种子的化合物安全性的评估.
- 开发3D定量结构-活动关系 (QSAR) 模型.
主要成果:
- 优化的FA衍生物对C. higginsianum,H. maydis和P. grisea.表现出显著的抑制活性.
- 在FA上替换5基可显著增强抗真菌功效.
- 特定衍生品的EC50值达到C. higginsianum的1.2微克/毫升,P. grisea.的12.0微克/毫升.
- 确定了16种主要化合物,这些化合物具有农业真菌杀菌剂开发的巨大潜力.
结论:
- 酸衍生物,特别是那些具有修饰的5-丁基组的衍生物,代表了一类有前途的农业杀菌剂.
- 鉴定到的化合物需要进一步的研究和商业应用的优化.
- QSAR建模为理解结构-活性关系和设计更强大的FA基杀菌剂提供了一个框架.
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