高剂量脂质体安二乙的安全性和有效性:系统性审查和元分析
Alternative therapies in health and medicine
|November 16, 2023
概括
高剂量的脂质体安波特素B (HD-L-AMB) 在治疗侵入性真菌感染方面没有显著的益处. 这种高剂量配方与增加的死亡率,较低的存活率和更多的不良反应有关,包括功能障碍.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 关键护理医学 关键护理医学
背景情况:
- 病房感染和侵入性真菌感染的发病率不断上升.
- 根深蒂固的真菌是越来越常见的医院获得感染的原因.
研究的目的:
- 系统地评估高剂量脂质体安二 B (HD-L-AMB) 的有效性,死亡率,存活率和不良反应.
主要方法:
- 10项随机对照试验 (RCT) 的元分析,包括1661名患者.
- 这些研究来自主要的数据库 (PubMed,Embase,Scopus,Web of Science,Cochrane).这些数据库中的研究被检索出来.
- 主要结局:整体治疗效果;次要结局:死亡率,生存率,不良反应.
主要成果:
- 在抗感染治疗中,HD-L-AMB没有显示出显著的治疗优势.
- 用HD-L-AMB治疗侵入性阿斯伯吉路斯感染与高死亡率和低存活率 (OR = 0.57) 有关.
- 与常规剂量L-AMB相比,HD-L-AMB观察到更高的不良反应发生率,包括功能障碍.
结论:
- 高剂量的脂质体安二B在治疗侵入性真菌感染方面没有明显的优势.
- HD-L-AMB与增加的死亡率,减少的长期存活率以及更高的不良事件风险,特别是功能衰竭有关.
- 建议在使用HD-L-AMB时谨慎使用,特别是当标准治疗对抗时.
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