超强度:刺激剂的使用和艾滋病毒的发病因子
Emily J Ross1, Renessa S Williams2, Michael Viamonte1
1University of Miami Miller School of Medicine, Miami, FL, USA.
Current HIV/AIDS reports
|November 16, 2023
概括
艾滋病毒感染者的兴奋剂使用与更高的病毒载量有关,即使是作为预防 (TasP) 的治疗. 需要进一步的研究来了解影响艾滋病毒管理的免疫变化和社会因素.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 神经科学是一个神经科学.
背景情况:
- 艾滋病毒治疗作为预防 (TasP) 的时代改善了病毒抑制率.
- 需要明确刺激剂的使用如何影响艾滋病毒病毒载量和艾滋病毒感染者 (PWH) 的免疫功能.
研究的目的:
- 在TasP的背景下,审查兴奋剂使用对艾滋病毒病毒载量和免疫失调的影响.
- 探索潜在的治疗目标和干预策略.
主要方法:
- 对28项检查兴奋剂使用和艾滋病毒病毒载量的研究进行了系统审查.
- 分析了12项调查其他艾滋病毒疾病标志物的研究,包括肠道免疫和细胞免疫.
主要成果:
- 在28项研究中的23项中,使用兴奋剂与病毒载量升高独立相关.
- 初步证据表明,使用兴奋剂可能会改变肠道免疫功能障碍和细胞免疫力,尽管艾滋病毒治疗有效.
- 目前的研究往往缺乏关于健康的社会决定因素的背景.
结论:
- 兴奋剂的使用对优化TasP有效性构成了重大障碍.
- 了解刺激剂使用中的微生物组-肠-大脑轴对于开发药物疗法至关重要.
- 解决社会决定因素的多层次干预对于综合护理至关重要.
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