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催化迁移交叉合反应:选择性C-H功能化的新机遇

You Wang¹, Yuli He², Shaolin Zhu^1,3,4

¹State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.

Accounts of chemical research

|November 16, 2023

概括

这项研究引入了催化迁移交叉合,这是一种通过功能化远程C-H键合成复杂分子的多功能方法. 它详细介绍了sp3和sp2C-H功能化的进展,为具有挑战性的结构提供了新的路线.

科学领域:

有机金属化学有机金属化学
催化剂是一种催化剂.
合成有机化学合成有机化学

背景情况:

通过金属迁移的迁移交叉合对于选择性C-H键的功能化至关重要.
催化迁移功能化为复杂分子合成提供了传统交叉合的替代方案.
最近的进展侧重于将1,n-Ni/H转移与交叉合合在一起,以实现高效的合成.

研究的目的:

审查最近催化迁移交叉合反应的进展.
突出迁移功能化模式,多种功能化和控制策略的进步.
讨论这些新方法的机械见解和合成应用.

主要方法:

通过代的1,2-Ni/H转移选择性交叉合开发Ni催化迁移sp3的C-H功能化.
在现场使用反极性或氧化还原中性方法生成Ni(II) H物种.
实施一个联体继电器催化策略,用于不对称的迁移性交叉合.
通过1,4-Ni/H转移选择性交叉合建立Ni催化迁移sp2的C-H功能化.

主要成果:

创建了一个使用基或基化物进行Ni-催化迁移sp3 C-H功能化的平台.
实现了多种功能化,包括碳化,氨化和硫化.
一个连接体中继策略使有效的不对称的迁移交叉合成为可能,克服了选择性挑战.
通过1,4-Ni/H转移报告了一种通过Ni催化迁徙sp2C-H功能化的新平台,可实现模块化二功能化和立体选择性烯合成.

结论:

催化迁移性交叉合代表了合成化学的重大进步.
开发的方法为复杂的分子架构提供了高效和选择性的途径.
连接物设计,新迁移模式和机理学研究的持续研究将进一步扩大这一领域.

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