从下丘脑到上核的氧化激素投射驱动了小鼠的识别记忆
Junpei Takahashi1, Daisuke Yamada1, Wakana Nagano1
1Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
PloS one
|November 16, 2023
概括
腹腔下垂体核 (PVN) 中的内源性催产素 (OXT) 神经元增强对象识别记忆. 激活这些OXT神经元向超母细胞核 (SuM) 投射,可以提高小鼠的记忆性能.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 内分泌学 在内分泌学.
背景情况:
- 催产素 (OXT) 神经元分布广泛,但内源性OXT在认知功能中的作用尚不清楚.
- 以前的研究表明外源性OXT会影响认知,需要对内源性机制进行调查.
研究的目的:
- 研究内源性催产素 (OXT) 在调节认知功能的作用,特别是小鼠对象识别记忆.
- 确定涉及OXT介导认知效应的特定神经通路.
主要方法:
- 利用设计者药物独家激活的设计者受体 (DREADD) 系统,专门激活小鼠中的OXT神经元.
- 使用新型对象识别任务 (NORT) 评估对象识别内存.
- 通过对c-Fos的免疫组合化学染色证实了神经元激活,并追踪了从偏心室下垂体核 (PVN) 到上核 (SuM) 的OXT阳性纤维.
主要成果:
- 激活OXT神经元显著增加了在北方的新物体探索时间.
- 在OXT神经元激活后,在超母细胞核 (SuM) 中观察到通过c-Fos表达表示的神经元活动的增加.
- 从PVN投射到SuM的OXTergic轴突的直接激活也增强了新型对象的探索.
结论:
- 腹腔下垂体核 (PVN) 中的内源性催产素 (OXT) 神经元在调节对象识别记忆方面发挥着至关重要的作用.
- 从PVN OXT神经元到超母细胞核 (SuM) 的投影途径对于调解这些增强记忆效应至关重要.
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