在结核病治疗期间,主要的不良心血管事件和高尿路血症
Hong-Joon Shin1,2, Joon-Young Yoon1, Young-Ok Na1
1Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Republic of Korea.
PloS one
|November 16, 2023
概括
肺结核 (TB) 治疗中使用pyrazinamide (PZA) 治疗超尿血是常见的,但这项研究发现它没有增加主要不良心血管事件 (MACE). 事实上,结核病治疗期间的高尿血与更好的患者结局有关.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 结核病 (TB) 治疗期间经常发生超尿血,特别是在使用皮拉津胺 (PZA) 时.
- 结核病患者的高尿血和主要不良心血管事件 (MACE) 之间的关联需要进一步调查.
研究的目的:
- 调查结核病治疗患者中高尿血和MACE发病率之间的关系.
- 探索超尿血症在结核病治疗期间对患者结果的影响.
主要方法:
- 进行了一项单一中心回顾性队列研究,涉及1143名在2010年1月至2017年6月期间接受治疗的结核病患者.
- 超尿血症被定义为血清尿酸水平>7.0毫克/分升男性和>6.0毫克/分升女性.
- 使用后勤回归分析来评估高尿血,MACE和死亡率之间的关联.
主要成果:
- 在82.3%的患者中检测到高尿路血,其中94.6%接受PZA.
- 以前的缺血性心脏病与MACE的发展有显著的关联 (OR, 14.087),而高尿路血症没有 (OR, 1.505).
- 对于没有耐药结核病的患者,高尿血与较低的死亡率 (OR,0.316) 和更好的结局有关.
结论:
- 尽管在使用PZA治疗结核病期间存在高尿路血,但它与MACEs的风险增加无关.
- 结核病治疗期间的高尿路血可能与改善患者的治疗结果有关,这可能反映出更好的治疗坚持.
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