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Updated: Jul 11, 2025

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SOS1和KSR1调节MEK抑制剂对基于PI3K和KRAS突变状态的耐药细胞群的反应反应

Brianna R Daley1, Heidi M Vieira2, Chaitra Rao2

  • 1Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814.

Proceedings of the National Academy of Sciences of the United States of America
|November 16, 2023
PubMed
概括

向SOS1或KSR1使用特拉美丁尼布可以克服KRAS突变癌症的耐药性. 删除KSR1恢复了敏感性,而PIK3CA的交换限制了SOS1抑制的有效性.

关键词:
在KSR1中,KSR1是KSR1.拉斯拉斯拉斯拉斯拉斯拉斯拉斯拉斯拉斯这就是SOS1的意义.电阻的阻力可以特拉美丁尼布 (trametinib) 是一种药物.

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