婴儿疼痛与父母抑制的疼痛:对大脑的立即和持久影响,疼痛和影响
Gordon A Barr1,2, Maya Opendak3,4, Rosemarie E Perry3,4
1Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
PloS one
|November 16, 2023
概括
父母的存在缓冲婴儿老鼠的短期疼痛,但重复暴露会改变长期疼痛和社会行为发展. 疼痛的早期社会缓冲影响神经发育轨迹不同于仅仅疼痛.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 行为科学 行为科学
背景情况:
- 父母的存在可以在短期内缓冲婴儿的疼痛反应.
- 重复的社会缓冲疼痛可能会导致长期不良影响.
研究的目的:
- 调查婴儿大鼠疼痛社会缓冲的短期和长期影响.
- 为了比较社交缓冲与单独疼痛对神经行为结果的影响.
主要方法:
- 婴幼鼠 (产后第8天和第12天) 接受了轻微的尾巴冲击,无论母亲是否在场.
- 分析了基因表达,Fos蛋白水平和行为反应.
- 幼在敏感的发育时期 (PN5-9或PN10-14) 暴露于重复的冲击母亲配对,以评估长期的成年结果.
主要成果:
- 母亲的存在减少了疼痛行为,USV和Fos表达在PN12的特定大脑区域.
- 在PN12的社会缓冲诱导了与GPCRs和神经发育相关的基因表达的显著变化.
- 早期生活 (PN5-9) 冲击母亲配对减少了成人疼痛敏感性和改变了社会行为,而后来的配对 (PN10-14) 对疼痛的影响较小,但影响了恐惧反应.
结论:
- 在早期发育过程中在社会背景下经历疼痛会改变神经行为反应.
- 婴儿疼痛的重复社会缓冲启动了疼痛和影响处理的独特发展轨迹,与仅仅经历疼痛相比.
- 这些发现强调了早期社会环境在编程长期疼痛和情绪调节方面的关键作用.
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