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基于Bredigite的生物活性神经指导导管用于治疗性巨细胞极化和外围神经再生

Yaowei Xuan¹, Lin Li¹, Xuelai Yin²

¹State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.

Advanced healthcare materials

|November 16, 2023

概括

布雷吉特生物陶神经导管通过增强细胞生长,髓化和血管化来促进神经再生. 这种生物材料创造了一个有利于愈合的环境,改善了外围神经损伤模型中的功能恢复.

科学领域:

生物材料科学生物材料科学
再生医学是一种再生医学.
组织工程是组织工程.

背景情况:

周围神经损伤对功能恢复提出了重大挑战.
有效的神经引导管道 (NGC) 对于弥合神经间隙至关重要.
开发先进的生物材料是改善神经修复结果的关键.

研究的目的:

为了研究布雷迪吉特 (BRT) 生物陶作为制造NGC的材料.
评估BRT的生物相容性和亲再生性质.
在外围神经损伤模型中评估BRT装载NGC的有效性.

主要方法:

使用BRT生物陶制造NGC.
在体外评估BRT对施万细胞 (RSC96) 和内皮细胞 (HUVEC) 的影响.
在体外评估BRT对巨细胞的免疫调节作用 (RAW 264.7).
在老鼠坐骨神经缺陷模型中,在体内植入带有BRT的NGCs.

主要成果:

BRT表现出良好的生物相容性和持续释放的Ca2+,Mg2+和Si4+离子.
BRT促进了施万细胞的增殖,髓化和内皮细胞的血管化.
BRT调节的巨细胞转向一个亲治疗 (M2类) 现型.
装有BRT的NGC改善了神经电生理学,并在体内减少了肌肉缩.
BRT促进了轴突的再生,再血管化和M2类巨细胞的透.

结论:

布雷迪吉特生物陶是NGC制造的一个有前途的材料.
通过调节免疫微环境和调节细胞过程,BRT促进神经再生.
装有BRT的NGC为外围神经修复提供了一种安全,有效和经济的方法.

关键词:

生物陶是生物陶的组成部分.这是一个bredigite.巨细胞的两极分化神经引导管道的神经引导管道外围神经的再生和再生

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