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石墨烯氧化物-脂单层的结构:一个牧场发生率X射线衍射和中子和X射线反射性研究研究

M Dolores Merchán¹, Nisha Pawar², Andreas Santamaria³

¹Departamento de Química Física, Facultad de Ciencias Químicas, Universidad de Salamanca, E37008 Salamanca, Spain; Grupo de Nanotecnología, Universidad de Salamanca, E37008 Salamanca, Spain; Laboratorio de Nanoelectrónica and Nanomateriales, USAL-NANOLAB, Universidad de Salamanca, E37008 Salamanca, Spain.

Journal of colloid and interface science

|November 16, 2023

概括

石墨烯氧化物 (GO) 通过静电和分散力与肺表面活性剂DPPC强烈相互作用. 在DPPC单层中插入GO并不会显著改变脂质单元细胞结构.

科学领域:

纳米技术纳米技术
生物物理学的生物物理.
材料科学材料科学材料科学

背景情况:

石墨烯氧化物 (GO) 纳米技术在生物医学和光电子领域至关重要.
了解GO纳米粒子毒性,特别是肺表面活性剂相互作用,由于广泛使用,至关重要.
兰木尔单层有效地模拟了肺表面活性剂的特性和纳米粒子效应.

研究的目的:

研究石墨烯氧化物 (GO) 板和1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine (DPPC) 脂质单层之间的相互作用.
阐明脂/GO相互作用的结构基础.
确定GO在DPPC膜中的位置和影响.

主要方法:

表面压力面积等热体.
中子和X射线反射 (NR/XRR).
在含有或未含有GO的化和化DPPC上进行草地发射X射线衍射 (GIXD).

主要成果:

在GO和DPPC的zwitterionic形式之间观察到强烈的相互作用.
在DPPC单层的异形链,头组和亚相水中发现了GO.
静电吸引力和分散力都对GO/DPPC相互作用有所贡献.
插入GO并没有显著改变DPPC单元细胞结构.

结论:

石墨烯氧化物 (GO) 通过静电和分散力与DPPC肺表面活性剂强烈相互作用.
在多个位置将GO集成到DPPC单层中,而不会破坏脂质的核心结构.
这项研究为GO纳米颗粒与肺表面活性成分的生物物理相互作用提供了基础的见解.

关键词:

空气-水接口是什么?迪帕米托伊尔-sn-glycerol-3-phosphocholine-phosphocholine-glycerol-3-phosphocholine-dipalmitoyl-sn-glycerol-3-phosphocholine-dipalmitoyl-sn-glycerol-3-phosphocholine-glycerol-3-phosphocholine-glycerol-3-phosphocholine-dipalmitoyl-sn-glycerol-3-phosphocholine-dipalmitoyl-sn-glycerol-3-phosphocholine-dipalmitoyl-sn-glycerol-3-phosphocholine-dipalmitoyl-sn-glycerol-3-phosphocholine-glycerol-3-phosphocholine-glycerol-3-phosphocholine-glycerol-3-phosphocholine-glycerol-3-phosphocholine-glycerol-3-phosphocholine-glycerol-3-phosphocholine-glycerol-3-glycerol-3-phosphocholine-glycerol-3-phosphocholine-phosphocholine 石墨烯氧化物石墨烯氧化物放牧事件X射线衍射折射事件中子反射计中子反射计.在X射线反射测量中使用X射线反射计.

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