在脉冲旋转速度下,微轴血中不稳定的流量结构的分析
Chenghan Chen1, Mingkui Zhang2, Pengfei Hao3
1Applied Mechanics Laboratory, Department of Engineering Mechanics, School of Aerospace Engineering, Tsinghua University, Beijing, PR China; Department of Cardiovascular Surgery, First Hospital of Tsinghua University, Beijing, PR China.
Computer methods and programs in biomedicine
|November 16, 2023
概括
皮肤穿透式心室辅助器件 (pVADs) 中的脉动流量没有显著增加血液溶解. 脉冲通过压力影响血液溶解,而变速增加了流动的不稳定性,其中运输效应最为显著.
科学领域:
- 生物医学工程 生物医学工程
- 心血管生理学心血管生理学
- 流体动力学 流体动力学
背景情况:
- 室腔辅助器件 (VAD) 的持续流动可能会导致出血和高血压等并发症.
- 对于皮肤通道VADs (pVADs) 探索脉冲流策略,以模仿生理状态.
- 脉冲流 pVAD 中的血液溶解潜力尚未得到充分理解.
研究的目的:
- 评估在脉冲流条件下运行的皮肤室内辅助器件 (pVADs) 中血液溶解的潜力.
- 为了研究可变旋转速度对pVADs血液溶解的影响.
- 分析在脉冲流中导致血解的流体动力学.
主要方法:
- 用可变速度的心力衰竭模型来模拟脉动的流量.
- 使用计算机流体动力学 (CFD) 和血液溶解预测模型.
- 使用正确的直角分解 (POD) 分析来详细描述流场特征.
主要成果:
- 引入可变旋转速度并没有显著增加pVADs中的血液溶解积累.
- 脉冲主要通过压力 (正常压力) 影响血液溶解.
- 可变的旋转速度增加了流动的不稳定性,通过运输和剪切效应影响了血液溶解,运输占主导地位.
结论:
- 在pVAD中不稳定的流量状态会影响血液溶解的空间分布.
- 对于pVADs的控制策略和螺旋设计,应考虑不稳定的流量对血液溶解的影响.
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