发生喘,喘恶化和与喘相关的住院病例在topic皮肤炎患者中
Joy Wan1, Sonia Wang2, Daniel B Shin2
1Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Md.
The journal of allergy and clinical immunology. In practice
|November 16, 2023
概括
亚托皮肤炎 (AD) 在儿童和成人中显著增加了喘风险. 更严重的AD与喘恶化和住院住院的可能性更高相关.
科学领域:
- 皮肤病学和肺病学
- 流行病学 流行病学
- 临床研究 临床研究
背景情况:
- "阿托皮游行"假说表明,阿托皮性皮肤炎 (AD) 和喘的发展之间存在联系.
- 然而,AD对发生性喘及其严重程度的确切影响仍然不完全理解.
研究的目的:
- 调查亚托邦性皮肤炎 (AD) 与患喘的风险之间的联系.
- 评估AD对喘患者喘恶化和住院治疗的影响.
主要方法:
- 一项大规模的队列研究利用了1994年至2015年的英国通用医疗电子健康记录.
- 患有AD的儿童和成年人的倾向与没有AD的个人相匹配.
- 根据治疗和专家转诊,AD严重程度被分类;结果包括喘事件和喘相关事件.
主要成果:
- 患有阿兹海默症的儿童患喘的风险增加了2倍 (HR, 1.96).
- 患有AD的成年人患喘的风险增加了38% (HR, 1.38).
- 患有AD的喘患者经历了恶化 (21-63%) 和住院 (20-64%) 的风险增加,随着AD的严重程度而升级的风险.
结论:
- 亚托邦性皮肤炎与儿童和成年人群中喘发病风险增加显著相关.
- 喘症的严重程度与喘患者中喘恶化和住院病例的剂量依赖性增加直接相关.
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