欧洲呼吸系统技术标准:全球肺功能倡议 (Global Lung Function Initiative) 对排气的氧化分数 (FENO) 的参考值
Marieann Högman1, Cole Bowerman2,3, Luis Chavez3
1Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.
The European respiratory journal
|November 16, 2023
概括
由于设备的可变性,为排出的氧化 (FENO) 制定参考方程是具有挑战性的. 在为喘监测建立人口参考值之前,标准化FENO测量至关重要.
科学领域:
- 肺部医学 肺部医学
- 呼吸系统生理学 呼吸系统生理学
- 生物标志物 生物标志物
背景情况:
- 呼出的氧化分数 (FENO) 升高表明T-辅助剂2驱动的呼吸道炎症.
- 在喘诊断和监测方面,ENO有助于喘.
研究的目的:
- 导出全球肺功能倡议对FENO的参考方程.
- 确定FENO的正常的上限.
主要方法:
- 从多个国际站点收集并协调了个别的FENO数据.
- 分析了健康个体的数据,使用了通用添加模型 (GAMLSS).
主要成果:
- 分析了来自34,782名个人 (8,022名健康人) 的数据.
- 身高,年龄和性别仅解释了FENO变化的12%.
- FENO设备类型显著影响了健康范围和上限,即使在标准化设备中也仍然存在大量异质性.
结论:
- 现有的FENO数据显示出单个参考方程的变化太多.
- 对FENO设备和测量协议的标准化对于获得可靠的人口参考值至关重要.
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