儿童瘤学的味觉变化:纵向评估
Ida Mehrdadi1, Neeraj Dhaliwal1, Lauren Chakkalackal1
1Child Health Evaluative Sciences, Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada.
BMJ supportive & palliative care
|November 16, 2023
概括
在接受癌症治疗的儿童中,口味变化很常见,在诊断时影响了38.3%,并在六个月内下降. 恶心,口腔干燥和温克里斯治疗被确定为这些味道变化的危险因素.
科学领域:
- 在瘤学瘤学.
- 儿科医学 儿科医学
- 临床营养学 临床营养学
背景情况:
- 味觉变化是儿童癌症治疗的常见副作用.
- 了解口味变化的流行率和影响因素对于支持性护理至关重要.
研究的目的:
- 为了确定六个月的儿童癌症患者口味变化的患病率.
- 为了确定癌症治疗期间与味道变化相关的因素.
主要方法:
- 一项纵向研究包括60名新诊断患有癌症的儿科患者 (4-18岁).
- 在六个月的月度采访中,评估了口味的变化,干预的成功以及对饮食的影响.
- 用通用线性混合效应模型来评估风险因素.
主要成果:
- 38.3%的患者在基线报告了味道变化,在六个月后下降到21.7%.
- 常见的变化包括食物的味道不同,不好或平淡,影响食物的享受和摄入量.
- 恶心,口腔干燥和最近接受的温克里斯治疗是独立的危险因素.
结论:
- 新诊断的儿科癌症患者中口味变化很普遍,但随着时间的推移而下降.
- 恶心,口腔干燥和温克里斯是引起味道变化的重要危险因素.
- 需要进一步的研究,以开发有效的干预措施,以管理这一群体的口味变化.
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