中央早期青春期:对诊断,治疗和结果的审查
Erika L Zevin1, Erica A Eugster1
1Division of Pediatric Endocrinology, Department of Pediatrics, Riley Hospital for Children at Indiana University Health, Indiana University School of Medicine, Indianapolis, IN, USA.
The Lancet. Child & adolescent health
|November 16, 2023
概括
中部早熟性青春期 (CPP) 是下丘脑-垂体-腺 (HPG) 轴的早期激活. 用性腺激素释放激素类似物治疗的目的是改善成人身高并使发育正常化.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 生殖医学 生殖医学
- 遗传学 遗传学 是一个
背景情况:
- 中部早熟性青春期 (CPP) 涉及过早激活下丘脑 - 垂体 - 淋巴腺 (HPG) 轴.
- 症状包括女孩早期乳腺发育和男孩丸扩大.
- 原因范围从内病理和类固醇暴露到异常和单一的因素.
研究的目的:
- 审查CPP的病理生理学,风险因素,诊断和管理.
- 概述目前对CPP的理解和治疗策略.
- 突出未来研究领域,特别是心理效应.
主要方法:
- 关于CPP的综合文献综述.
- 诊断标准的总结,包括临床,生化,放射和遗传测试.
- 对治疗方式的概述,重点是释放性腺激素的激素类似物.
主要成果:
- 诊断CPP需要多学科的评估.
- 释放性荷尔蒙类比疗法是标准的治疗方法.
- 治疗的目的是优化成人身高和心理社会发展.
结论:
- 有效的CPP管理需要及时诊断和适当的治疗.
- 目前治疗的长期结果通常是积极的.
- 对CPP心理影响的进一步研究是有必要的.
相关概念视频
Signs of Puberty
368
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
368
Attention-Deficit/Hyperactivity Disorder
68
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
68
Adrenal Gland Disorders
1.6K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.6K


