有知识的专家是否可以像无知者一样评估成本和结果? 精准医学评估中的一个实验
Thamonwan Dulsamphan1, Parntip Juntama1, Chotika Suwanpanich1
1Health Intervention and Technology Assessment Program, Ministry of Public Health, Nonthaburi, Thailand.
International journal of technology assessment in health care
|November 16, 2023
概括
建议使用盲目方法来评估精密药物,因为它更好地反映了专家判断任务中的反事实情景. 这种方法确保专家在没有事先诊断信息的情况下评估结果,提高研究有效性.
科学领域:
- 医疗信息学 医疗信息学
- 卫生经济学 卫生经济学
- 遗传学 遗传学 是一个
背景情况:
- 专家判断对于评估精密药物至关重要.
- 评估反事实情景是理解治疗价值的关键.
- 标准方法可能会受到可用的诊断信息的影响.
研究的目的:
- 评估标准专家判断方法对精密药物的有效性.
- 在专家判断任务中比较"盲目"与"无盲目"的方法.
- 评估专家对儿童中精准医学使用结果的估计.
主要方法:
- 十四位临床医生估计了儿科中外体序列测序的成本和结果.
- 专家被随机分配到"无盲" (有结果) 或"盲" (没有结果) 组.
- 两个小组都估计了没有exome测序的反事实场景的结果.
主要成果:
- 该研究发现,盲目和非盲目方法之间没有显著差异.
- 参与者和案例的小样本大小可能具有有限的统计能力.
- 关于诊断信息对专家判断的影响,结果是不确定的.
结论:
- 建议使用盲目方法进行精准医学评估的专家判断.
- 盲目方法更准确地代表了反事实情景.
- 需要进一步的研究以更大的样本大小来证实这些发现.
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