优化,表征和毛囊向评估的三胺和双胺载荷的阴阳体
Parisa Ghasemiyeh1,2, Fatemeh Moradishooli1,3, Saeid Daneshamouz3
1Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Scientific reports
|November 17, 2023
概括
这项研究开发了用于局部治疗的新型阴茎体,成功地将三胺和双胺直接输送到毛囊中,以提高疗效和减少副作用.
科学领域:
- 皮肤病学和制药科学 皮肤病学和制药科学
- 纳米技术在药物输送中的应用
- 配方科学科学 配方科学
背景情况:
- 一般性显著影响青少年和年轻人的心理健康.
- 局部疗法通过将药物不良反应降到最低,比全身疗法更有优势.
- 克服角层屏障仍然是有效的局部皮肤透的关键挑战.
研究的目的:
- 为了制造含有三胺 (TRT) 和双胺 (BCT) 的体,具有囊向的潜力.
- 使用Design-Expert软件优化阴茎细胞的配方.
- 描述优化的阴茎细胞体,并评估它们在体内毛囊向能力.
主要方法:
- 使用薄膜水化技术制备了装载着三胺和双胺的体.
- 使用Design-Expert软件进行了配方优化.
- 特性包括粒子大小,泽塔潜力,传输电子显微镜,药物负载和差异扫描热量计. 在体内对毛囊向的评估是使用罗达胺B载荷的基体进行的.
主要成果:
- 优化后的体呈现出一个球形形状,平均直径为319.20±18.50nm,泽塔电位为-29.70±0.36mV.
- 高捕获效率 (>94%) 和负载能力 (约. 对于双胺和三胺,均达到了1.4%) 的水平.
- 在体内研究表明,毛囊中存在显著的体积累,这表明毛囊向成功.
结论:
- 开发的阴茎细胞共递送系统有效地封装了三胺和双胺.
- 体体表现出优异的物理化学特性和显著的卵泡向潜力.
- 这种新的细菌体配方显示出对先进的一般性管理有前途.
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