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Updated: Jul 11, 2025

Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR
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Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR

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使用SPTCR-seq的高灵敏度空间解析T细胞受体测序

Jasim Kada Benotmane1,2,3, Jan Kueckelhaus1,2,3, Paulina Will1,2,3

  • 1Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany.

Nature communications
|November 17, 2023
PubMed
概括

空间T细胞受体测序 (SPTCR-seq) 能够详细分析癌症中的T细胞功能障碍. 这种新方法准确地重建了T细胞受体结构,揭示了瘤内的免疫细胞相互作用.

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相关概念视频

RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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