炎症标志物预测新诊断的肝硬化患者的存活率:一项前性注册研究
Thit Mynster Kronborg1, Henry Webel2, Malene Barfod O'Connell3
1Gastro Unit, Medical Division, Hvidovre University Hospital, Hvidovre, Denmark. thit.mynster.kronborg@regionh.dk.
Scientific reports
|November 17, 2023
概括
炎症标志物可以预测新诊断的肝硬化患者的180天死亡率. 这些标志物与死亡率有显著的相关性,为肝病患者提供预后价值.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
背景情况:
- 炎症在肝硬化中明显,并与脱补偿相关.
- 系统性炎症标志物可能为肝病患者提供预后信息.
研究的目的:
- 研究新诊断的肝硬化患者的炎症标志物与180天死亡率和住院患者之间的相关性.
- 开发和验证使用炎症标志物和临床数据的死亡率和入院预测模型.
主要方法:
- 从149名新诊断的肝硬化患者收集了血样本.
- 量化了92个炎症标志物,并在180天内注册了死亡/入院病例.
- 开发了后勤回归模型,并使用86名患者的单独队列验证了它们.
主要成果:
- 在92个炎症标志物中,有20个与180天死亡率显著相关 (q值为0.00-0.044).
- 在炎症标志物和肝脏相关的入院之间没有发现显著的相关性.
- 预测模型实现了接受器运行特征曲线 (AUROC) 下的区域,死亡率为0.73-0.79,入院率为0.61-0.73,在死亡率预测方面表现更好.
结论:
- 炎症标志物是新诊断的肝硬化病患者180天死亡率的有价值的预测指标.
- 目前的预测模型需要进一步验证,才能在肝硬化患者的临床实施.
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