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Updated: Jun 11, 2026

Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro
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灵长类动物特有的ZNF808对于人类的胰腺发育至关重要

Elisa De Franco1, Nick D L Owens1, Hossam Montaser2

  • 1Institute of Clinical and Biomedical Sciences, University of Exeter Faculty of Health and Life Sciences, Exeter, UK.

Nature genetics
|November 17, 2023
PubMed
概括

灵长类动物特异性基因ZNF808中的功能丧失变异因扰乱胰腺早期发育而导致胰腺产生. 这突显了灵长类动物特异性基因组区域在人类先天性疾病中的作用.

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Efficient Generation of Pancreas/Duodenum Homeobox Protein 1+ Posterior Foregut/Pancreatic Progenitors from hPSCs in Adhesion Cultures

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相关概念视频

Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...