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新的ex vivo方法客观地评估胰岛素的空间皮下分散通过时间在基率基础的管理期间的时间

Pauline Jacquemier^1,2, Yann Retory^3,4,5, Clara Virbel-Fleischman²

¹Institut Necker Enfants Malades (INEM), IMMEDIAB Laboratory, Université de Paris Cité, INSERM U1151, Paris, France.

Scientific reports

|November 17, 2023

概括

这项研究引入了一种新的实时成像方法,用于跟踪1型糖尿病患者皮下组织中胰岛素的传播. 该技术揭示了胰岛素分散的变化,有助于优化胰岛素治疗.

科学领域:

生物医学工程生物医学工程
医疗成像医学成像
内分泌学在内分泌学.

背景情况:

在使用胰岛素的1型糖尿病患者中,血糖的变化很常见.
疑似来自的皮下 (SC) 胰岛素传播异质性,但不太了解.

研究的目的:

开发和验证一种用于监测SC胰岛素传播的新型实时外体实验方法.
量化胰岛素仓储分散及其在输注期间的可变性.

主要方法:

结合高精度成像 (微型CT) 与同时测量人类皮肤的压力.
开发了一个新的分散指数 (IoD) 来分析随时间推移的3D胰岛素仓库细分.
以每小时1UI的速度进行3小时的输液,每5分钟拍摄一次图像.

主要成果:

开发的方法成功地实时可视化了SC胰岛素的传播.
对所有注射剂的IOD随着时间的推移而增加,这表明分散的演变.
皮下注射显示了最小的测试间变化.
观察到的压力升高与组织中的气泡相关.

结论:

这种新的成像和压力测量技术为SC胰岛素输液动态提供了宝贵的见解.
该方法可用于比较不同的胰岛素参数和输液特性.
进一步的研究可以优化胰岛素治疗,并改善1型糖尿病的血糖控制.

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