在前列腺癌放射治疗后出现二次恶性瘤的风险
Tenaw Tiruye1,2, Rowan David3,4, Michael O'Callaghan3,4,5,6
1Cancer Epidemiology and Population Health Research Group, Allied Health and Human Performance, University of South Australia, North Terrace, SAHMRI Building, Adelaide, 5001, Australia. Tenaw.Tiruye@unisa.edu.au.
Scientific reports
|November 17, 2023
概括
与接受激进前列腺切除术 (RP) 的男性相比,接受前列腺癌外部束辐射疗法 (EBRT) 治疗的男性患二次性泌尿器和肺癌的风险更高. 总体而言,二次癌症风险在治疗方法之间没有显著差异.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 癌症流行病学 癌症流行病学
背景情况:
- 前列腺癌治疗决策包括权衡疗效与潜在的长期副作用.
- 外部辐射疗法 (EBRT) 和激进前列腺切除术 (RP) 是前列腺癌的主要治疗方法.
- 了解这些治疗后二次癌症的比较风险对于患者咨询和管理至关重要.
研究的目的:
- 调查EBRT治疗前列腺癌患者中二次癌症的累积发病率与RP治疗.
- 为了比较两个治疗组之间的整体和局部特异性二次癌症的风险.
- 为了确定治疗方式和随后恶性瘤的发展之间的潜在关联.
主要方法:
- 来自南澳大利亚的全州链接数据分析包括2002年至2019年间被诊断患有前列腺癌的男性.
- 二次癌症的累积发病率估计在治疗后5至15年之间.
- 用细灰竞争风险分析和敏感性分析来评估风险差异.
主要成果:
- 总共分析了7625名患者 (54%的RP,46%的EBRT).
- 接受EBRT治疗的患者年龄较大,并发病率较高,随访期间死亡的可能性更高.
- 调整后的模型显示,EBRT组与RP组相比,生殖尿道癌症 (aSHR2.29) 和肺癌 (aSHR1.93) 的风险明显更高. 对于整体,胃肠道,皮肤或血液癌症没有发现显著差异.
结论:
- 与激进前列腺切除术 (RP) 相比,前列腺癌的外部束辐射疗法 (EBRT) 与二次性泌尿器和肺癌的风险增加有关.
- 这些发现可能部分归因于治疗效应和潜在的未测量混因素.
- 需要进一步的研究来阐明这些观察到的风险的确切机制和长期影响.
相关概念视频
01:20Disorders of the Male Reproductive System
426
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
426
01:13Radiological Investigation III: Pulmonary Angiogram and PET Scan
95
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
95
02:59Biological Effects of Radiation
15.5K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
15.5K
01:30Skin Cancer
4.2K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.2K