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Updated: Jun 25, 2026

Efficient Derivation of Human Neuronal Progenitors and Neurons from Pluripotent Human Embryonic Stem Cells with Small Molecule Induction
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来自人类多能干细胞的基位神经元 (locus coeruleus) 的产生

Yunlong Tao1,2, Xueyan Li3, Qiping Dong3

  • 1Waisman Center, University of Wisconsin-Madison, Madison, WI, USA. taoyunlong@nju.edu.cn.

Nature biotechnology
|November 17, 2023
PubMed
概括

研究人员开发了一种方法,可以从干细胞中产生人体局部神经元 (LC-NE) 神经元. 这些功能神经元有助于研究神经疾病和开发新疗法.

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Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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The brainstem, located inferior to the brain and superior to the spinal cord, serves as a bridge between the cerebrum and the spinal cord. It plays a vital role in relaying information and controlling critical life functions. It comprises three primary regions: the midbrain, pons, and medulla oblongata.
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The cerebral cortex, a critical structure of the brain, is intricately divided into two hemispheres, each consisting of four distinct lobes: occipital, temporal, frontal, and parietal. These lobes function cooperatively to regulate various cognitive and sensory functions, forming the basis of our complex neural capabilities.
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