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饮食模式有助于塑造人类肠道微生物生态系统的粘膜模拟器中的肠道微生物群

Yorick Minnebo¹, Kim De Paepe¹, Jeroen Raes^2,3

¹Center for Microbial Ecology and Technology, Ghent University, Coupure Links 653, 9000 Ghent, Belgium.

FEMS microbiology ecology

|November 17, 2023

概括

饮食模式显著塑造了肠道微生物群. 时间限制的饮食,一顿饭的模式,改变了微生物组成,有利于像Faecalibacterium这样的有益细菌.

科学领域:

微生物组研究的研究.
营养科学营养科学
代谢健康代谢健康

背景情况:

饮食模式影响减肥和代谢健康.
关于饮食时间和频率如何影响不同结肠区域的肠道微生物群的研究有限.

研究的目的:

研究不同饮食模式对肠道微生物组合和功能的影响.
为了确定昼夜节律是否影响肠道微生物活动.

主要方法:

在动态肠道模型中,四个便微生物组接受了三个饮食模式:标准化,西方和时间限制.
分析了微生物的组成,生物质的生产和新陈代谢.
每4小时采样一次,以评估昼夜波动.

主要成果:

饮食模式对微生物组合有适度的影响 (比例变化为2.4%,定量变化为1.8%).
时间限制的饮食显著改变了微生物的丰度,增加了Bacteroides,Butyricicoccus,Dialister和Faecalibacterium.
在微生物生物质,组成或功能方面没有观察到显著的昼夜波动.
更长的禁食时间促进了生长较慢的细菌 (Akkermansia,Dialister,Parasutterella) 超过生长较快的细菌 (Pseudomonas,Stenotrophomonas).

结论:

饮食模式是肠道微生物组结构和功能的关键决定因素.
时间限制的饮食证明了对微生物群落的显著影响.
考虑饮食模式对于解释饮食干预研究结果至关重要.

关键词:

在体外肠道模拟器中M-SHIME 质量管理师QMP 质量管理师这就是SCFAFA.养频率养频率养频率肠道微生物生态学微生物细胞密度的密度

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