疫苗接种和关注变异对长期COVID临床表型的影响
Grace Kenny1,2, Kathleen McCann3, Conor O'Brien4
1Centre for Experimental Pathogen Host Research, University College Dublin, Belfield Dublin 4, Ireland. grace.kenny1@ucd.ie.
BMC infectious diseases
|November 17, 2023
概括
长期COVID症状模式随着新变种的出现而转移,显示胸痛和心的病例较少. 这些变化与令人担忧的变异有关,而不是疫苗接种状态.
科学领域:
- 医学研究 医学研究
- 传染病流行病学 传染病流行病学
- 公共卫生 公共卫生
背景情况:
- 长期COVID呈现了一系列异质的症状,需要对不同症状模式进行研究.
- 了解这些模式对于开发针对性治疗长期COVID至关重要.
- 引起关注的变种 (VOC) 和疫苗接种策略的出现可能会影响长期COVID症状.
研究的目的:
- 在长期COVID患者中识别和描述症状集群.
- 调查VOC和疫苗接种对长期COVID症状集群的发展的影响.
主要方法:
- 采用了前性的多中心队列研究设计.
- 根据急性COVID-19感染的时间,参与者被分为野生类型 (WT) 和关注变种 (VOC) 组.
- 多重对应分析 (MCA) 和层次聚类被用于识别症状群,随后进行后勤回归来分析症状关联.
主要成果:
- 分析包括417名个人 (268名WT,149名VOC).
- 在两组中都发现了三个类似的症状集群 (肌肉骨,心肺呼吸系统和不太症状).
- 与WT组相比,VOC组表现出心和胸痛的频率降低,这些差异归因于变体而不是疫苗接种.
结论:
- 长期COVID表型似乎随着新变种的出现而演变,其特点是心和胸痛的发病率减少.
- 观察到的症状表现的变化主要与变种的引入有关,而不是与疫苗接种状态有关.
- 需要进一步的研究才能充分理解这些不断变化的症状模式的长期影响.
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