在初级SARS-CoV-2感染后长期的幽默和细胞免疫力:20个月的纵向研究
Astrid Korning Hvidt1,2, Huaijian Guo3, Rebecca Andersen1,2
1Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.
BMC immunology
|November 17, 2023
概括
长期的SARS-CoV-2免疫力在大多数人群中持续到感染后20个月,T细胞反应更持久. 接种COVID-19疫苗可以提高Spike特异性免疫力,增强保护.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 传染性疾病 传染性疾病
背景情况:
- 严重急性呼吸系统综合征 冠状病毒2 (SARS-CoV-2) 感染和接种疫苗诱导特定免疫力.
- 了解SARS-CoV-2感染后的长期免疫反应轨迹至关重要,但有限.
研究的目的:
- 为了研究SARS-CoV-2感染后的长期免疫反应.
- 确定幽默免疫和细胞免疫的持续时间,感染后长达20个月.
主要方法:
- 对93名SARS-CoV-2康复个体进行了长度队列研究.
- 监测尖端和核囊特异性IgG抗体水平.
- 使用ICS和AIM测定评估T细胞对Spike和非Spike表位素的反应 (CD4+和CD8+).
主要成果:
- 核囊特异性抗体和非Spike特异性T细胞频率在20个月内下降.
- 大多数人保持了持久的免疫力:59%的核体IgG血清阳性,>70%的非尖端T细胞持续存在.
- 接种COVID-19疫苗可以提高斯派克特异性IgG和T细胞的反应,达到类似或高于感染后的水平.
结论:
- 针对SARS-CoV-2的特定免疫力,特别是T细胞反应,在感染后的20个月内仍然存在.
- 细胞免疫表现出比抗体水平更大的耐用性.
- 疫苗接种有效地增强了斯派克特异性反应,有助于对SARS-CoV-2的持续保护.
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