在各种宫内皮瘤中阴道微生物群的特征:一个横截面研究
Yiran Liu1, Shuzhen Wang2, Jun Liu3
1Department of Obstetrics and Gynecology, Beijing Chaoyang Hospital Affiliated With Capital Medical University, 8 Gongti South Road, Chaoyang District, Beijing, 100020, China.
Journal of translational medicine
|November 17, 2023
概括
阴道微生物组合在宫内皮质瘤 (CIN) 等级发生变化时发生变化. 从乳杆菌和伪杆菌转变为加德内拉,普雷沃特拉和迪亚斯特,表明子宫癌的风险增加.
科学领域:
- 微生物组研究的研究.
- 妇科瘤学 妇科瘤学
- 人类乳头瘤病毒 (HPV) 感染.
背景情况:
- 宫内皮质瘤 (CIN) 的进展与阴道微生物组的改变有关.
- 了解这些变化可以帮助预防过度治疗,并预测侵袭性宫癌.
- 阴道微生物组与HPV感染和CIN发展有关.
研究的目的:
- 研究不同程度的宫内皮瘤 (CIN) 患者的显著微生物特征.
- 确定微生物生物标志物,用于早期检测和治疗宫癌前体.
主要方法:
- 高通量16S核糖体RNA (16SrRNA) 测序用于分析阴道微生物群 (VMB) 社区组成.
- 这项研究包括692名患有高风险人类乳头瘤病毒 (HR-HPV) 感染的中国妇女.
主要成果:
- 随着CIN等级的增加,Lactobacillus和Pseudomonas的显著下降被观察到.
- 相反,加德内雷拉,迪阿里斯特和普雷沃特拉的比例在较高的CIN等级下显著增加.
- 高度CIN显示出更大的VMB多样性和受影响的代谢途径,可能有助于早期宫癌的发展.
结论:
- 患有CIN的患者表现出一种特定的阴道微生物特征:乳酸菌/伪菌减少,加德内拉/普雷沃特拉/透菌增加.
- 这些微生物群落之间的平衡至关重要;破坏可能导致宫病变和致癌.
- 这些发现凸显了阴道微生物组在宫癌进展和预防中的作用.
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