YAP1/Piezo1涉及淋巴血管在UVR诱导的光衰老过程中的动态变化,进展到状细胞癌
Yuling L Yang1, Chu Zhou1, Qi Chen1
1Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.
Journal of translational medicine
|November 17, 2023
概括
这项研究研究了紫外线辐射 (UVR) 对皮肤的影响,揭示了适应性免疫微环境的变化. 8周和16-18周的关键转折点为皮肤状细胞癌 (cSCC) 的早期预测和干预提供了信息.
科学领域:
- 皮肤病学和瘤学
- 免疫学和癌症生物学
- 分子和细胞生物学分子和细胞生物学
背景情况:
- 皮肤状细胞癌 (cSCC) 是由紫外线引起的损伤引起的.
- 淋巴中心免疫微环境的变化对光衰老至cSCC进展至关重要.
- 了解这些机制可以确定用于早期cSCC预测的目标.
研究的目的:
- 调查在紫外线诱导的光衰老过程中淋巴中心免疫微环境的动态变化,以cSCC.
- 阐明潜在的机制,包括YAP1/VEGFC信号通路和淋巴血管生成.
主要方法:
- 利用TIMER2.0分析YAP1/VEGFC信号在头部和部状细胞癌 (HNSCC) 和其与生存的相关性.
- 在SKH-1无毛小鼠中通过累积的紫外线诱导光衰和cSCC,评估不同时间点的微环境.
- 评估了皮肤表型,淋巴和血管结构,T细胞透,Piezo1和VE-cadherin表达以及淋巴疏通功能.
主要成果:
- YAP1/VEGFC信号通路和淋巴血管 (LV) 密度与HNSCC的进展和存活有关.
- 在小鼠中,UVR暴露在8周 (光衰老) 和16-18周 (癌前阶段) 时显示出明显的转折点.
- LVs,Piezo1表达和免疫细胞透 (CD4 +,CD8 + T细胞) 的动态变化与皮肤状况的进展相关.
结论:
- 淋巴中心的免疫微环境通过YAP1/VEGFC和Piezo1调节适应持续的紫外线.
- 从光衰老到cSCC的进展涉及UVR暴露8周和16-18周的关键转折点.
- 监测YAP1,Piezo1,LVs和免疫细胞动态可以使cSCC的早期识别和及时干预成为可能.
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