压力和全静电负荷在患有初级开角玻璃眼患者
Kiran Gc1, Karthikeyan Mahalingam, Vivek Gupta
1Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Journal of glaucoma
|November 17, 2023
概括
主要开角格劳科马患者表现出更高的全静电负荷得分,表明慢性压力导致的生理失调. 通过改变生活方式来控制压力可能有助于减缓青光眼的进展并改善健康.
科学领域:
- 眼科医生 眼科 眼科
- 生理学 生理学 生理学
- 压力研究 压力研究
背景情况:
- 静态负荷 (AL) 反映了慢性压力的累积生理磨损.
- 主要开角青光眼 (POAG) 是不可逆转失明的主要原因.
- 了解AL和POAG之间的关系对于全面的患者管理至关重要.
研究的目的:
- 为了评估被诊断为初级开角玻璃眼 (POAG) 的患者的静电负荷.
主要方法:
- 一项涉及50名POAG患者和50名年龄相匹配的对照者的病例控制研究.
- 静态负荷使用13个生物标志物进行评估,包括血压,脂质,葡萄糖和皮质醇.
- 较高的AL得分 (≥4) 表示显著的生理失调.
主要成果:
- 与对照组相比,POAG患者的平均AL得分 (4.68±2.09) 显著高于对照组 (3.32±1.34).
- 像同类半氨酸,总胆固醇,高密度胆固醇和糖基化血红蛋白等成分在青光眼患者中显著增加.
- 高的AL得分与年龄较大,社会经济地位较低和青光眼严重程度相关,并且与视网膜神经纤维层厚度和视野平均偏差负相关.
结论:
- 青光眼患者表现出全静态过载,这表明与慢性压力相关的生理失调.
- 对于POAG患者,建议采用整体管理方法,包括改变生活方式以减少慢性压力.
- 这种方法可能有助于潜在地减缓疾病的进展,并提高整体健康结果.
相关概念视频
Open Angle Glaucoma: Treatment
458
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
458
Glaucoma: Overview
594
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
594
Angle Closure Glaucoma: Treatment
528
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
528
Hypertension II: Pathophysiology
10
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
10
Hypertension and Regulation of Blood Pressure
2.1K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
2.1K
Psychological Responses to Stress
56
Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
56


