在默认模式网络中,与脑震荡相关的枢纽连接中断与症状和认知有关
Heather C Bouchard1,2, Kate L Higgins1,3, Grace K Amadon1,4
1Center for Brain, Biology and Behavior, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Journal of neurotrauma
|November 17, 2023
概括
脑震荡会破坏大脑网络的通信,改变默认模式网络 (DMN) 中枢的连接. 这些变化与运动员受伤后的症状和视觉记忆缺陷有关.
科学领域:
- 神经科学是一个神经科学.
- 脑部成像 脑部成像
- 运动医学 运动医学
背景情况:
- 脑震荡会引起各种症状,但大脑的变化尚不清楚.
- 大脑枢纽对于网络功能至关重要,可能容易受到脑震荡损伤的伤害.
研究的目的:
- 在脑震荡后,量化默认模式网络 (DMN) 中枢的中断.
- 将功能连接性变化与症状和认知等临床结果联系起来.
主要方法:
- 在大学运动员 (n=44) 中使用休息状态的fMRI,在基线,急性创伤后和恢复.
- 收集自我报告的症状和认知数据.
- 分析了DMN和其他网络之间的连接.
主要成果:
- 脑震荡增加了DMN网络内连接,与更多的症状和更差的视觉记忆有关.
- 脑震荡减少了DMN枢纽与视觉网络的连接,与更少的体征症状和更好的视觉记忆有关.
- 基线和恢复之间连接性-临床结果关系没有显著差异.
结论:
- 急性脑震荡会改变DMN枢纽连接,影响症状报告和视觉记忆.
- 网络内部和网络之间的通信中断表明脑震荡后的网络效率低下.
- 这些发现提高了对脑震荡病理生理学和临床表现的理解.
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