相关实验视频
Updated: Jul 11, 2025
13:38
Fear Incubation Using an Extended Fear-Conditioning Protocol for Rats
Published on: August 22, 2020
8.3K
婴儿肠道微生物群和消极和恐惧反应
Venla Huovinen1, Anna-Katariina Aatsinki1,2, Eeva-Leena Kataja1
1Department of Clinical Medicine, Psychiatry, FinnBrain Birth Cohort Study, Turku Brain and Mind Center, University of Turku, Turku, Finland.
Development and psychopathology
|November 17, 2023
概括
婴儿早期肠道微生物群的组成与气质有关. 较高的肠道微生物多样性与增加的恐惧反应性相关,在消极反应性的男孩中观察到特定的微生物差异.
科学领域:
- 微生物组研究的研究.
- 发展心理学是发展心理学.
- 儿科医生精神病学 儿科精神病学
背景情况:
- 肠道微生物群组成 (GMC) 越来越多地与神经发育和行为结果有关.
- 早期的GMC与儿童气有关,但研究仍然有限.
- 了解这些早期的联系可能会为儿童精神疾病的干预提供信息.
研究的目的:
- 调查2.5个月的早期GMC与8个月和12个月的儿童负面和恐惧反应之间的联系.
- 为了确定后期儿童精神疾病的潜在中间表型.
- 探索肠道微生物群与气质关系中的性别特异性差异.
主要方法:
- 从FinnBrain出生队列研究中对330名婴儿的GMC进行16SrRNA测序的便样本分析.
- 通过8个月的实验室气质评估电池 (Lab-TAB) 和12个月的婴儿行为问卷修订简单表格 (IBQ-R SF) 来评估消极和恐惧反应.
- 统计分析以确定GMC指标和气质评估之间的关联.
主要成果:
- 在肠道微生物α多样性和报告的恐惧反应性之间发现了积极的关联.
- 根据男孩的负反应性,观察到微生物社区组成的差异.
- 同黄油酸与观察到的负反应性有相关性,尽管在线性模型中这种相关性减弱.
- 几种细菌系与特定的婴儿气质特征有显著的关联.
结论:
- 婴儿肠道微生物群的组成与早期气质特征有关,包括恐惧和负面反应.
- 研究结果表明,肠道微生物组在塑造早期行为发展方面可能发挥作用.
- 这项研究为未来对幼儿时代肠-大脑轴的机械研究提供了基础.
相关概念视频
01:09Preparedness and Phobias
104
Human fear responses to certain stimuli, such as darkness, heights, deep water, and blood, can often arise despite the absence of direct negative experiences. This phenomenon is rooted in evolutionary psychology, which posits that humans have developed a predisposition to fear stimuli that historically posed significant survival threats. This predisposition, known as preparedness, suggests that early humans who developed a fear of potentially dangerous entities, such as venomous snakes and...
104
01:30Socioemotional Development during Infancy
55
Socio-emotional development in infancy is primarily shaped by early emotional responses and social connections, with temperament playing a central role. Temperament refers to the consistent patterns in an individual's emotional and behavioral responses, observable even in infancy. By examining temperament, researchers can better understand an infant's unique ways of interacting with the world, influencing subsequent personality and socio-emotional growth.
Primary Temperament Types
Primary Temperament Types
55
01:14Piaget's Stage 1 of Cognitive Development
628
The sensorimotor stage, the initial phase of Jean Piaget's theory of cognitive development, spans the first two years of a child's life. During this period, infants actively engage with their surroundings, building cognitive awareness through direct interaction with the world. This interaction is primarily based on sensory perception and motor actions, allowing infants to gradually understand basic physical properties and predict how objects interact within their environment.
628
01:23Anatomy of the Intestines
72.1K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
72.1K
01:20Attachment
63
Attachment is vital for infant development, as warm social interactions support growth and well-being. In a classic 1958 study by Harry Harlow, the significance of warmth and comfort in forming attachments was examined. Harlow separated newborn monkeys from their mothers and provided two artificial "mothers": one made of cold wire and the other covered in soft cloth. Despite the wire mother offering food, the infant monkeys preferred the comfort of the cloth mother, demonstrating that...
63
01:22Development of Immunocompetence
315
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
315