一种新发现的激活UCP1的化合物抑制了肥胖及其相关的代谢障碍
Ken Onodera1, Yutaka Hasegawa1, Nozomi Yokota1
1Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Iwate Medical University, Yahaba, Japan.
Obesity (Silver Spring, Md.)
|November 17, 2023
概括
研究人员发现了一种化合物,可以促进脂肪细胞的热生成,有助于体重控制和改善代谢健康. 这种化合物还发现了两个对能源消耗至关重要的新基因.
科学领域:
- 代谢研究研究 代谢研究
- 肥胖治疗方法 肥胖治疗方法
- 脂肪组织生物学 脂肪组织生物学
背景情况:
- 脂肪组织的热生成是对抗肥胖和代谢功能障碍的关键策略.
- 识别激活热生成途径的新型化合物对于开发有效治疗方法至关重要.
研究的目的:
- 为选促进脂肪细胞热生成的化合物.
- 阐明已识别的热源性化合物的代谢功能和作用.
- 为了确定参与解蛋白1 (Ucp1) 依存热生成的新基因.
主要方法:
- 使用基于细胞的平台对4800种不同的化合物进行高通量选,以诱导脂肪细胞中的Ucp1表达.
- 一种化合物的特征及其热生效应和细胞毒性.
- 在体内研究使用饮食诱导的肥胖小鼠模型.
- 涉及线粒体生物发生,呼吸和信号通路 (PKA-MAPK) 的机制研究.
主要成果:
- 确定了一种新型化合物,可以激活Ucp1,促进脂肪细胞热生成,细胞毒性最小.
- 用该化合物治疗的小鼠显示体重增加减少,胰岛素敏感性增强,能量消耗增加.
- 该化合物增加了线粒体生物发生和最大呼吸,部分通过PKA-MAPK通路.
- 确定了两个新的Ucp1-依赖的热生成基因,Kcnc2和Gm5627.
结论:
- 已识别的化合物显示出作为治疗肥胖和相关代谢障碍的治疗剂的潜力.
- 新发现的基因Kcnc2和Gm5627在Ucp1依赖热生成中起着重要作用.
更多相关视频
06:08Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
Published on: May 19, 2023
2.1K
09:20An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function
Published on: May 4, 2021
3.7K
相关概念视频
01:30Regulation of Food Intake
245
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
245
01:09GPCRs Regulate Adenylyl Cylase Activity
5.6K
Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
5.6K