用端粒酶激活的Au@DNA纳米机用于向的化学光动力学协同疗法
Yun-Jie Zhou1, Jing Zhang1, Dong-Xiao Cao1
1State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Centre for Analytical Sciences, College of Chemistry, Nankai University Tianjin 300071 PR China tanganna@nankai.edu.cn kongdem@nankai.edu.cn.
RSC medicinal chemistry
|November 17, 2023
概括
一种新型纳米机器使用癌症激活化疗和光动力疗法 (PDT).
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 在瘤学瘤学.
背景情况:
- 癌症治疗往往涉及多种模式,以提高疗效.
- 有针对性的药物输送系统对于最小化非目标副作用至关重要.
- 端粒酶是一种在许多癌细胞中过度表达的酶,具有潜在的治疗点.
研究的目的:
- 设计和评估用于协同癌症治疗的智能可激活纳米机器.
- 为了实现化学疗法和光动力学剂的向输送.
- 为了使治疗有效载荷的端粒酶响应激活.
主要方法:
- 设计了一种纳米机器,用于PTK7向,其中包含Sgc8受体.
- 整合端粒酶敏感元件以控制药物释放.
- 在体外和体内研究,以评估治疗疗效和向.
- 使用多克索鲁比 (DOX) 作为化疗剂和Ce6作为光敏感剂.
主要成果:
- 该纳米机器专门针对过度表达PTK7.7的癌细胞.
- 端粒酶激活触发了用于化疗的DOX的释放.
- 根据端粒酶释放的Ce6标记的体激活光动力学疗法 (PDT).
- 在缺少端粒酶的情况下,PDT激活被抑制,减少了目标外损伤.
结论:
- 开发的纳米机器为协同癌症治疗提供了一个智能,可激活的平台.
- 端粒酶是连续化疗和PDT激活的特定触发剂.
- 这种方法表明了改善癌症治疗的潜力,并减少了副作用.
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