肝移植后免疫抑制的长期并发症
Rohit Mehtani1, Sanjiv Saigal2
1Department of Hepatology, Amrita Institute of Medical Sciences and Research, Faridabad, Haryana - 121001, India.
Journal of clinical and experimental hepatology
|November 17, 2023
概括
肝移植 (LT) 后的长期免疫抑制改善了生存率,但增加了诸如感染和恶性瘤等并发症. 尽量减少药物剂量,同时防止排斥是改善患者生活质量的关键.
科学领域:
- 移植医学 移植医学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 由于更好的免疫抑制,肝移植 (LT) 的结果有所改善.
- LT后的长期存活率与免疫抑制药物的并发症增加有关.
- 副作用可以是药物特定的,类特定的或通用的.
研究的目的:
- 审查肝移植后长期免疫抑制的并发症.
- 为了确定这些并发症的相关风险因素.
- 讨论降低免疫抑制相关风险的策略.
主要方法:
- 关于肝移植后与免疫抑制药物相关并发症的文献综述.
- 对药物特异性 (例如,氨酸抑制剂,类固醇) 和通用效应的分析.
- 综合有关风险因素和缓解策略的当前知识.
主要成果:
- 氨酸抑制剂与功能衰竭,移植后糖尿病 (PTDM) 和代谢综合征有关.
- 类固醇有助于糖尿病,骨质疏松症和代谢综合征.
- 感染和新发性恶性瘤 (DNMs) 与累积免疫抑制有关.
结论:
- 尽量减少累积免疫抑制对于降低LT后的发病率和死亡率至关重要.
- 均衡免疫抑制与异体移植排斥预防对于长期患者健康至关重要.
- 免疫抑制相关并发症的有效管理可以改善肝移植后的生活质量.
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