美国人口中骨指数和糖尿病风险 - 一个案例研究
Gaelle Lemdjo1, André Pascal Kengne2,3, Brice Nouthe4
1Endocrinology Unit, Jordan Medical Service, Yaounde, Cameroon.
Journal of diabetes and metabolic disorders
|November 17, 2023
概括
膀骨指数 (HFI) 与2型糖尿病 (T2DM) 风险有关,特别是在男性中. 这种身体结构标志物为T2DM预测提供了超越传统肥胖度量的宝贵见解.
科学领域:
- 内分泌学 在内分泌学.
- 流行病学 流行病学
- 人体生理学 人体生理学
背景情况:
- 糖尿病风险存在持续的变化,即使考虑到肥胖.
- 膀骨指数 (HFI),是上臂与上腿长度的比例,与2型糖尿病 (T2DM) 相关,尚未得到广泛研究.
研究的目的:
- 调查骨指数 (HFI) 与2型糖尿病 (T2DM) 患病率之间的关联.
- 评估HFI的增量值作为T2DM风险预测的潜在标记.
主要方法:
- 这是一项基于人口的横截面研究,利用了国家健康和营养检查调查 (1999-2018) 的数据.
- 分析包括42,088名30岁及以上的成年人.
- HFI被计算为上臂长度/上腿长度的比率. T2DM结局包括诊断和未诊断的病例.
主要成果:
- 观察到T2DM患病率上升的显著趋势,HFI的四分位数较高 (P < 0.0001).
- 在男性的不同BMI和腰围模式中,HFI和T2DM之间的关联保持一致,但在女性中没有.
- 纳入HFI改善了T2DM预测模型的歧视,男性为60.0%,女性为51.1%.
结论:
- HFI可能是导致T2DM风险的身体结构的一个重要因素.
- 升高的HFI与男性T2DM患病率的增加有关,独立于BMI和腰围.
- HFI显示出作为T2DM风险评估的额外工具的潜力.
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