在中枢神经系统受伤时使用荷尔蒙避孕的观点
Hari Pradhyumnan1, Gina G Perez1, Shahil H Patel1
1Peritz Scheinberg Cerebral Vascular Disease Research Laboratory (CVDRL), Department of Neurology, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, USA.
Journal of neurotrauma
|November 17, 2023
概括
口服避孕药 (OC) 可能影响中枢神经系统 (CNS) 损伤的妇女,如脊髓损伤和创伤性脑损伤. 需要进一步的研究来了解这些复杂的相互作用及其对健康的影响.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
背景情况:
- 生育年龄的女性在自然生命阶段经历激素波动.
- 含有雌激素和孕激素的口服避孕药 (OC) 被生育年龄的女性广泛使用.
- 中枢神经系统 (CNS) 的损伤,如脊髓损伤 (SCI) 和创伤性脑损伤 (TBI),可以发生在这些生殖年.
研究的目的:
- 审查中枢神经系统损伤对内源性卵巢激素的影响,反之亦然.
- 讨论口服避孕药 (OC) 产生的外源性卵巢激素对中枢神经系统的影响.
- 确定有关内源性和外源性激素对中枢神经系统损伤结果的联合影响的知识差距.
主要方法:
- 文献综述和现有研究的综合.
- 讨论潜在的机制和后果.
- 在实验室,流行病学和临床研究中确定未来研究领域.
主要成果:
- 长期使用OC与血液凝固问题和内皮功能障碍等风险有关.
- 对OC使用的潜在神经心理影响包括情绪波动和认知障碍.
- 对于内源性和OC影响的外源性激素如何影响中枢神经系统损伤结果的理解有限.
结论:
- 进一步调查至关重要,以了解卵巢激素,OC使用和中枢神经系统损伤之间的相互作用.
- 对于临床和流行病学研究,需要意识到潜在的复杂后果.
- 未来的研究应该专注于阐明使用OC的中枢神经系统损伤的女性的机制和改善患者护理.
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