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肺癌老年患者免疫检查点抑制剂:来自第三期试验的证据

Li Wang¹, Juan Zhou¹, Xin Yu¹

¹Department of Medical Oncology.

Current opinion in oncology

|November 17, 2023

概括

免疫检查点抑制剂 (ICI) 对老年肺癌患者有希望,但临床试验不足以代表这一人口群体. 需要进一步的研究来证实它们在老年人中的有效性和安全性.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
老年医学老年医学

背景情况:

肺癌是全球癌症死亡的主要原因之一.
老年患者 (≥70岁) 占肺癌病例的很大一部分.
关于免疫检查点抑制剂 (ICI) 对老年肺癌患者的疗效的数据有限,原因是临床试验中的代表人数不足.

结论:

审查了评估老年肺癌患者ICI的III期试验.
总结了第一线/第二线单一疗法和组合疗法的结果.
强调需要为这一群体制定更具包容性的临床试验设计.

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