对成年人患有血液性恶性瘤的呼吸道病毒感染的回顾性分析
1Department of Medical Microbiology, University of Health Science, Başakşehir Çam and Sakura City Hospital, Istanbul, Turkey. kamuran67@gmail.com.
European review for medical and pharmacological sciences
|November 17, 2023
概括
呼吸道病毒感染在成年血液性恶性瘤患者中很常见,甲型流感,SARS-CoV-2和鼻病毒/肠病毒是常见的. 呼吸短促显著增加了这些脆弱患者的死亡风险.
科学领域:
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 血液性恶性瘤 (HM) 损害免疫功能,增加对呼吸道感染的易感性.
- 呼吸道病毒感染对HM患者构成重大威胁,可能导致严重后果.
研究的目的:
- 评估在被诊断为HM的成年患者中呼吸道病毒感染的患病率和特征.
- 确定与呼吸道病毒感染相关的风险因素及其对该患者群体死亡率的影响.
主要方法:
- 从怀疑呼吸道感染的成年HM患者的医疗记录的回顾性分析.
- 实时聚合酶连锁反应 (RT-PCR) 测试在鼻/鼻样本上.
- 统计分析以确定病原体的频率,相关症状和死亡风险.
主要成果:
- 检测到的HM患者中有43.04%的呼吸道病毒PCR结果呈阳性.
- 流感A (10.13%),SARS-CoV-2 (8.86%) 和鼻病毒/肠病毒 (7.59%) 是最常见的病原体.
- 患有急性髓性白血病 (AML) 的患者,症状,咳和特定的放射性发现显示出更高的测试阳性. 呼吸障碍与5.85倍的死亡风险增加有关.
结论:
- 呼吸道病毒组PCR阳性在AML,症状感染,咳和特定放射性发现的HM患者中较高.
- 呼吸短促是呼吸道病毒感染的HM患者高死亡风险的关键指标.
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