围产期结局和长期住院治疗三胞胎根据出生顺序
David Nadav Sabag1,2, Gali Pariente2, Eyal Sheiner2
1Joyce and Irving Goldman Medical School, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Birth (Berkeley, Calif.)
|November 17, 2023
概括
三胎妊娠中的出生顺序与婴儿对于妊娠年龄 (SGA) 较小的风险增加有关. 然而,出生顺序对三胞胎后代的长期住院风险没有影响.
科学领域:
- 围产儿医学 围产儿医学
- 新生儿科学 新生儿科学
- 儿科研究成果研究结果
背景情况:
- 在双胞胎怀孕中,出生顺序与不良结果的关联被确立.
- 关于三胎妊娠产后结果和长期健康状况的出生顺序影响的数据有限.
研究的目的:
- 根据三胞胎的出生顺序,调查三胞胎的近产期结果和长期住院情况.
- 评估出生顺序是否影响三胎妊娠后代不良健康事件的风险.
主要方法:
- 在第三级医疗中心对117例三胞胎分娩 (1991-2021) 的回顾性队列研究.
- 立即围产期结局和住院病例的比较,直到18岁.
- 使用通用估计方程 (GEE) 模型和考克斯比例危险模型进行统计分析.
主要成果:
- 怀孕年龄 (SGA) 较小的比例随着出生顺序的增加 (15.4%为第三个兄弟姐妹,6.0%为第一个兄弟姐妹).
- 第三个出生与SGA独立相关 (调整的OR3.0).
- 根据出生顺序,心血管,呼吸,神经或感染相关住院没有发现显著差异.
结论:
- 在三胎妊娠中,出生顺序与SGA的风险增加有关.
- 尽管存在SGA关联,但出生顺序似乎没有影响三胞胎后代长期住院的风险.
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