核向纳米战略调节时空通信,实现双重抗瘤免疫力
Ben Wang1, Zhi-Chao Hu1, Li-Jie Chen2
1Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Advanced healthcare materials
|November 17, 2023
概括
这项研究引入了一种针对核的光动力学纳米战略,以增强抗瘤免疫力. 新型纳米颗粒激活了先天性和适应性免疫,导致长期免疫记忆和瘤抑制.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 纳米技术纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 瘤细胞和免疫细胞通信,影响瘤的进展.
- 目前的疗法往往侧重于抑制负面的瘤免疫相互作用 (例如PD-L1/PD-1).
- 增强积极的瘤免疫沟通仍然是一个重大挑战.
研究的目的:
- 开发一个核向的光动力学纳米战略,以改善积极的细胞间通信.
- 激活双重抗瘤免疫 (先天性和适应性) 以加强癌症治疗.
- 为了在瘤微环境中建立对免疫反应的时空控制.
主要方法:
- 用光敏感剂 (Ce6) 装载的mSiO2-Ion@Ce6-NLS纳米颗粒的设计,并用离子液 (离子) 和核定位信号 (NLS) 进行修改.
- 使用核向光动力学疗法 (nPDT) 诱导免疫细胞死亡和DNA释放.
- 研究巨细胞通过干扰素基因信号的刺激器和树突细胞通过"吃我"信号的激活.
主要成果:
- nPDT促进了瘤细胞中受损的双链DNA的释放.
- 通过激发干扰素基因信号传递和树突细胞激活的巨细胞激活.
- 实现了CD8+T细胞的招募和瘤免疫微环境的重塑.
- 长期免疫记忆和显著抑制瘤生长和复发被证明.
结论:
- 开发的核向光动力学纳米战略有效地增强了积极的瘤免疫通信.
- 这种方法成功地激活了双重抗瘤免疫力,从而产生了强大的抗癌效应.
- 该战略有望克服癌症免疫治疗方面的挑战,并预防瘤复发.
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