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铁醇对二二甲引起的急性毒性对大鼠的影响

Mehmet Çömez¹, Mustafa Cellat², Müslüm Kuzu³

¹Department of Anesthesiology and Reanimation, Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkey.

Journal of biochemical and molecular toxicology

|November 17, 2023

概括

提洛索尔的预处理可以防止迪克洛芬雅克引起的脏损伤. 这项研究表明,tyrosol.

科学领域:

药理学和毒理学药理学和毒理学
腎臟病學 (nephrology) 是一種醫學專業.
生物化学生物化学

背景情况:

狄克洛菲纳克 (DCF) 是一种常见的NSAID,在长期使用或过量服用时可能会导致脏损伤.
了解DCF毒性机制对于制定保护策略至关重要.

研究的目的:

调查提洛索尔 (Tyr) 预处理对大鼠迪克洛菲纳克诱导的损伤的保护作用.
评估与DCF暴露和Tyr治疗相关的生化和组织病理变化.

主要方法:

32只老鼠被分为四组:对照组,DCF,DCF+Tyr和Tyr.
生物化学参数 (肌素,尿素,BUN,GSH,MDA,GPx,CAT) 和分子标记物 (COX-2,NF-κB,Tnf-α,Nrf-2,IL-1β) 进行了分析.
脏组织被用阴道病理学检查.

主要成果:

服用DCF会增加血清肌素,尿素和BUN以及脏MDA水平,同时降低GSH和GPx活性.
DCF增加了COX-2,NF-κB和Tnf-α,并降低了Nrf-2水平.
铁醇预处理显著逆转了这些生化和分子变化,缓解了诸如管状退化和亡等组织病理损伤.

结论:

铁醇具有显著的保护作用,可以防止二二甲引起的毒性.
铁醇的保护机制涉及其抗炎和抗氧化特性,调节关键的氧化应激和炎症通路.
铁醇是一种潜在的治疗剂,可以预防NSAID相关的损伤.

关键词:

这是一种抗炎药物.抗氧化剂是一种抗氧化剂.狄克洛芬雅克 (Diclofenac) 是一种可怕的药物.毒性毒性毒性泰洛索尔 (tyrosol) 是一种类型的硫酸盐.

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