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通过使用带电纳米粒子和弱外部电场来增强细胞膜的透性

Hideya Nakamura1, Takumi Okamura1, Masaya Tajima1

  • 1Department of Chemical Engineering, Osaka Metropolitan University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan. hideyanakamura@omu.ac.jp.

Physical chemistry chemical physics : PCCP
|November 17, 2023
PubMed
概括

带电纳米粒子和微弱的电场增强了细胞膜的透性,使药物能够传递. 这种方法允许化合物穿过膜而不会造成损伤,提供了一种新的细胞内输送策略.

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Bioavailability Enhancement: Drug Permeability Enhancement01:27

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After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...