制药联合晶体形成的可扩展性通过机械化学在批量
Alexander Bodach1, Anaïs Portet2, Frederik Winkelmann1
1Department of Heterogeneous Catalysis, Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, D-45470, Mülheim an der Ruhr, Germany.
ChemSusChem
|November 17, 2023
概括
机械化学使得无溶剂,大规模生产药品联合晶体,如ibuprofen-nicotinamide. 这种绿色化学方法与工业制药制造业的可持续性目标保持一致.
科学领域:
- 绿色化学和制药制造业的发展
- 机械化学和可持续技术
背景情况:
- 机械化学是一个快速发展的领域,与绿色化学原则保持一致.
- 这项技术支持联合国可持续发展目标和欧洲绿色协议目标.
研究的目的:
- 通过机械化学证明一个活性药物成分 (API) 联合晶体的工业规模,无溶剂的生产.
- 根据绿色化学的十二个原则,评估机械化学过程对环境的影响.
主要方法:
- 使用一个工业异常振动磨床进行批量加工.
- 准备的伊布洛芬-尼古丁胺胺 (rac-IBP:NCT) 共同晶体的数量,按千克尺度计.
- 使用DOZN 2.0绿色化学评估器进行定量评估.
主要成果:
- 通过无溶剂的机械化学批量工艺成功扩大rac-IBP:NCT联合晶体的生产规模.
- 证明了工业应用机械化学联合晶体合成的可行性.
- 量化评估了该过程是否符合绿色化学原则.
结论:
- 机械化学为制药共晶生产提供了一个可持续和工业上可行的途径.
- 无溶剂的机械化学过程是实现更绿色制药制造的关键.
- 这种方法有助于制药行业的环境可持续性.
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