在血液流动下可视化纳米级滑剂层
Jun Ki Hong1,2,3,4,5, Isaac J Gresham1,5, Dan Daniel6,7
1School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.
ACS applied materials & interfaces
|November 17, 2023
概括
结合液态 perfluorocarbons (TLPs) 通过保留液态 perfluorocarbon (LP) 层来保持抗血栓性质. 优化的TLP在血液流动下表现出稳定的纳米级滑膜,防止凝块形成.
科学领域:
- 生物材料科学 生物材料科学
- 表面化学 表面化学
- 医疗设备工程 医疗设备工程
背景情况:
- 连接液体 perfluorocarbons (TLPs) 的设计是为了减少医疗器械上的血块形成.
- 保持液态高碳 (LP) 层的稳定性对于TLP抗血栓疗效至关重要,尤其是在生理血液流动条件下.
研究的目的:
- 在模拟生理剪切流下,研究和量化TLP表面上的LP层的现场稳定性.
- 要确定在TLP表面保留的纳米级滑膜是否足以防止血栓形成.
主要方法:
- 使用共聚焦双波长反射干扰对比显微镜用于现场滑剂厚度映射.
- 暴露在TLP涂层玻璃基板上的糖醇/水混合物或全血的剪切流量约为2900s-1.1.
- 在未经处理的玻璃上量化滑剂耗尽与随着时间的推移优化TLP表面.
主要成果:
- 在切割流开始时,多余的滑油 (>2μm) 被移除.
- 未经处理的玻璃表面在1分钟内完全耗尽滑剂.
- 优化的TLP表面保留了纳米级滑膜 (100nm2μm) 长时间 (几十分钟).
结论:
- 优化的TLP表面在生理剪切流下表现出纳米级滑膜的显著稳定性.
- 这些保留的纳米尺度膜有效地防止红细胞和血小板的粘附,证实了抗血栓性质.
- 这些发现支持TLP技术在先进的血液接触医疗器械方面的潜力.
关键词:
抗血栓性物质是一种抗血栓性物质.生物界面生物界面生物材料是一种生物材料.与焦点一致的干扰测量液体注入的表面.连接的液体 perfluorocarbon 是一个连接的液体 perfluorocarbon.更多相关视频
07:23Fabrication of Nanoheight Channels Incorporating Surface Acoustic Wave Actuation via Lithium Niobate for Acoustic Nanofluidics
Published on: February 5, 2020
5.8K
09:19In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
Published on: May 24, 2020
9.0K
相关概念视频
Blood Flow
Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
Design Example: Deciding Thickness of Lubricating Fluid in a Shaft
Effective lubrication between a rotating shaft and its bearing housing is essential in rotating machinery to minimize friction, wear, and energy loss. With carefully controlled thickness and viscosity, the lubricant layer prevents metal-to-metal contact, ensuring smooth operation.
To calculate the required thickness of the lubricant layer, the tangential velocity at the shaft's surface must first be determined. This velocity is calculated by converting the rotational speed to angular velocity...
To calculate the required thickness of the lubricant layer, the tangential velocity at the shaft's surface must first be determined. This velocity is calculated by converting the rotational speed to angular velocity...
