胎盘孕激素及其受体在艾滋病毒感染的孕前妇女
Serisha Sewnarain1, Shoohana Singh2, Thajasvarie Naicker2
1Optics and Imaging Centre, College of Health Sciences, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Private Bag X7, Congella, Durban, 4013, KwaZulu-Natal, South Africa. serishasewnarain@gmail.com.
Histochemistry and cell biology
|November 17, 2023
概括
这项研究发现,胎盘前和孕受体水平在妊娠前 (PE) 和艾滋病毒阳性怀孕中较低. 这些缺陷可能会损害胎盘,并有助于PE的发展,特别是在早期发病的情况下.
科学领域:
- 生殖生物学和免疫学
- 孕产妇和胎儿的医学
- 传染病病理学 传染病病理学
背景情况:
- 在南非艾滋病毒感染和孕前 (PE) 的高患病率需要了解它们的协同效应.
- 孕激素 (P) 和孕激素受体 (PR) 在胎盘发育和功能中起着至关重要的作用.
- 之前的研究表明,荷尔蒙失衡可能导致PE的发病.
研究的目的:
- 为了比较感染艾滋病毒的孕产妇前列腺前列腺和正常压力的孕妇中孕产妇前列腺 (P) 和孕产妇前列腺受体 (PR) 的胎盘免疫分泌.
- 调查早期发病的PE (EOPE) 和晚发病的PE (LOPE) 对P和PR表达的影响.
- 在PE的背景下,探索P/PR表达和艾滋病毒状况之间的关系.
主要方法:
- 利用免疫组织化学和形态图像分析来量化胎盘P和PR表达.
- 跨组免疫表达水平的比较:PE与正常压力,EOPE与LOPE,以及HIV+与HIV-.
- 分析了P和PR表达在交换和导向小的表达.
主要成果:
- 与正常血压对照组相比,PE患者在交换小中显著降低了P和PR免疫表达 (p < 0.0001).
- 与LOPE相比,在EOPE观察到减少的P和PR表达,与艾滋病毒感染者相比,在HIV+观察到减少的P和PR表达.
- 胎盘P和PR免疫表达在PE和HIV感染的联合存在下降调节,特别是影响早期发病的PE.
结论:
- 胎盘P和PR免疫表达在患有先兆子和艾滋病毒感染的妇女中显著下调.
- 联合抗逆转录病毒疗法 (cART) 可能导致缺陷的P合成,影响 trofhoblast入侵和PE发展.
- 在EOPE中观察到的P和PR的减少证实了它们在正常安置过程中的关键作用.
相关概念视频
01:24Gonadal and Placental Hormones
1.5K
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
1.5K
01:15Transcytosis of IgG
2.8K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
2.8K