在艾滋病毒感染者中,不确定潜力的克隆性血液形成
Andreas D Knudsen1,2, Christian Winther Eskelund3, Thomas Benfield4
1Department of Infectious Diseases 8632.
AIDS (London, England)
|November 17, 2023
概括
在艾滋病毒感染的老年人中,超过四分之一患有克隆性血液形成 (CHIP). 在这个人群中,CHIP与炎症或冠状动脉疾病 (CAD) 无关.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 心脏病学 心脏病学
背景情况:
- 不确定潜力的克隆性血液形成 (CHIP) 与衰老,炎症和冠状动脉疾病 (CAD) 风险有关.
- 感染艾滋病毒 (PWH) 的老年人往往会增加炎症和CAD风险.
- 在PWH中CHIP,炎症和CAD之间的关系尚不清楚.
研究的目的:
- 为了确定老年PWH中CHIP的患病率.
- 调查CHIP和炎症标志物之间的关联.
- 探索CHIP和CAD在较老的PWH中的关联.
主要方法:
- 来自哥本哈根艾滋病毒感染共发病率 (COCOMO) 研究的数据分析,包括55岁以上的190名PWH.
- CHIP定义为变异性等位基因分数≥2%.
- 通过CT血管造影评估CAD,将严重程度分类为从无动脉样硬化到阻塞性CAD (≥50%狭窄).
主要成果:
- 在26%的参与者中发现了CHIP突变,DNMT3A,TET2和ASXL1是最常见的.
- CHIP的患病率与年龄和性别有关,但与炎症标志物 (IL-1β,IL-6,TNF-α等) 无关. ) 的情况.
- 在调整后,CHIP和动脉样硬化或阻塞性CAD之间没有发现显著的关联.
结论:
- 在斯堪的纳维亚,超过四分之一的老年,接受良好治疗的PWH患者表现出CHIP.
- 这项研究没有发现证据表明CHIP与炎症标志物或CAD在这个队列中有关.
- CHIP不太可能是解释治疗HIV感染的炎症-CAD关联的机制.
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