孕前和静脉血栓栓塞的长期风险
Eva Havers-Borgersen1, Jawad H Butt1, Marianne Johansen2
1Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
JAMA network open
|November 17, 2023
概括
孕前显著增加了妇女在怀孕期间和之后发生静脉血栓栓塞 (VTE) 的风险. 这一发现凸显了改善临床管理策略的必要性,对于有先兆子史的妇女来说,以预防VTE.
科学领域:
- 产科和妇科 产科和妇科
- 心血管医学 心血管医学
- 血栓形成研究研究
背景情况:
- 静脉血栓塞栓症 (VTE) 是孕产妇死亡的主要原因.
- 孕前,一种怀孕障碍,涉及内皮功能障碍,可能会增加VTE风险.
- 关于孕前和VTE风险的现有研究存在争议.
研究的目的:
- 为了研究妊娠前和VTE风险之间的关联.
- 为了分析怀孕期间,产后期和产后期的VTE风险.
- 为了确定患有VTE风险较高的女性.
主要方法:
- 使用丹麦全国范围的注册表 (1997-2016) 进行的观察性队列研究.
- 包括原发性妇女,从怀孕到VTE诊断,死亡或研究结束.
- 从2023年1月到5月进行的统计分析.
主要成果:
- 孕前与43%的VTE风险增加有关 (调整HR 1.43).
- 在患有先兆子的妇女中观察到深静脉血栓和肺栓塞的增加率.
- 在怀孕,产后和产后期间的研究结果一致.
结论:
- 孕前与整个周产期的VTE风险显著增加有关.
- 即使调整了混因素,这种关联仍然存在.
- 需要进行进一步的研究,以优化在有先兆子史的妇女中进行VTE预防.
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